Recently, widespread vaccination with COVID-19 vaccine has become one of the main tools to control the outbreak. However, some individuals have experienced skin reactions after vaccination, which has raised concerns in the medical community. To better understand these reactions, physicians at the University Hospital of Geneva, Switzerland, conducted a single-center retrospective data analysis and published a report in the Journal of the European Academy of Dermatology and Venereology titled “Clinicopathological characterization of mRNA-based skin reactions after COVID-19 vaccine.
The report documented 11 skin reactions to two mRNA COVID-19 vaccines, BNT162b2 and mRNA-1273, between January and June 2021. The most common clinical manifestation of these was generalized erythema or purpura, while the drug reaction style was the most common histological manifestation. In addition, other types of skin reactions such as localized edema, nodules, and maculopapular rash were also mentioned in this report.
To better diagnose and manage these reactions, the report provides a detailed clinical and histologic classification and discusses the mechanisms that may lead to their occurrence. For example, because the injection site for COVID-19 mRNA vaccine is usually the upper arm, skin reactions may be related to trauma at the injection site. In addition, this report discusses the impact of allergic reactions, history of systemic disease, and other factors on skin reactions.
In conclusion, this report provides detailed information about skin reactions after COVID-19 mRNA vaccine and provides physicians with the opportunity to better diagnose and manage
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