The article titled “IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein” discusses the potential implications of repeated COVID-19 vaccinations, particularly mRNA vaccines, on the immune system.
The paper highlights that globally, around 13.38 billion COVID-19 vaccine doses have been administered, and 72.3% of the total population has been injected at least once with a COVID-19 vaccine. However, the immunity provided by these vaccines rapidly wanes, and their ability to prevent hospitalization and severe disease in individuals with comorbidities has recently been questioned.
The article discusses the discovery of abnormally high levels of IgG4 in people who were administered two or more injections of the mRNA vaccines. It suggests that an increase in IgG4 levels could have a protective role by preventing immune over-activation, similar to that occurring during successful allergen-specific immunotherapy by inhibiting IgE-induced effects.
However, emerging evidence suggests that the reported increase in IgG4 levels detected after repeated vaccination with the mRNA vaccines may not be a protective mechanism; rather, it constitutes an immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses.
Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals.
The paper concludes by emphasizing the need for further research to understand the full implications of repeated COVID-19 vaccinations on the immune system and overall health.
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