The research area of this article is SARS-CoV-2 by using in vitro cell lines, and the demonstration process is the discovery that the tip protein of SARS-CoV-2 can inhibit DNA damage repair and thus V(D)J recombination. V(D)J recombination is a mutational process of B-cell receptor (BCR) and T-cell receptor (TCR) that allows cells to produce multiple receptors, thus enhancing the diversity of the immune system.(Pages: 1,4,5,7,8,9)
The consequence of DNA damage repair is the inhibition of V(D)J recombination, which can lead to impaired autoimmunity and possible side effects.(Pages: 1,4,6,7,9,10)
A variety of study tools were used, including cell and cell culture, HR and NHEJ reporter assays, cell isolation and immunoblotting, comet assay, immunofluorescence, and V(D)J recombination assays.(Pages: 2,3,9) Through these study tools, it was concluded that SARS-CoV-2 Spike protein may inhibit V(D)J recombination and thus affect the variability of the immune system. The final conclusion is that the SARS-CoV-2 spike protein may suppress autoimmunity and highlights the possible side effects of a full-length spike vaccine. (Pages: 1,7,9,10)
The SARS-CoV-2 spike protein was used in the manufacture of some COVID-19 vaccines, such as those from Moderna and Pfizer. (Pages: 7,9,10) implying that the vaccine also has the same side effect of suppressing the immune system.
The authors of this paper are Hui Jiang and Ya-Fang Mei, and the paper was published by MDPI, an internationally recognized publisher and therefore highly credible.
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